Aborting America

determine nucleoside and nucleotide structure and the use of the data thus obtained to predict conformations of new molecules. Chemical synthesis schemes for the heterocyclic and sugar moieties and chemical properties of natural nucleosides and analogues are discussed. These are followed by reviews of the molecular mechanisms of action of selected antiviral and antineoplastic nucleoside analogues. These sections include general treatments, such as the theoretical bases for selective antiviral and antitumor activities, as well as particular treatment of the arabinosides, the as yet single clinically applicable systemic drug developed by nucleoside research. Further sections deal with the problematic design and interpretation of biological test systems for evaluation of antiviral and antineoplastic agents. Again, consideration is given to both theoretical and practical aspects. Some of the clinical uses of nucleosides are reviewed and the industrial development of new drugs is discussed. These articles are well-written and present a clear picture of the obstacles to success as well as the promise of future breakthroughs. They point out the poignant need for cooperation between the chemist, biochemist, pharmacologist, and clinician to improve the pace of progress in this field.